Synthesis and evaluation of turn-on fluorescent probes for imaging steroid sulfatase activities in cells.
نویسندگان
چکیده
We have synthesized and evaluated two self-immobilizing, turn-on fluorescent probes carrying a coumarin molecular framework for imaging intracellular human steroid sulfatase (STS) activity. The 8-fluoromethyl coumarin derivative, which gives stronger fluorescence response in the incubation study with STS preparations, was successfully applied to visualize STS activity in cells.
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 46 شماره
صفحات -
تاریخ انتشار 2014